Digital Creativity, Life Sciences, and My Life

Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling, Cell

Genome evolution and adaptation in a long-term experiment with Escherichia coli, Nature

David Haussler, Ph.D.

The human genome, with its 3 billion chemical bases that together spell out the recipe for life, is still largely unfamiliar territory. While most scientists have focused their attention on the stretches of DNA responsible for building proteins, which make up only a minute fraction of the human genome, Haussler studies the vast DNA regions that do not code for proteins, often called "junk" DNA. His research strongly suggests that this "junk" has biological relevance, including the regulation of genes that build proteins. Errors in this type of DNA also have been linked to genetic diseases. An expert in using computers to understand the enormous amount of data in the genome—a field called bioinformatics—Haussler wants to learn how noncoding regions control protein-coding genes. Additionally, his studies comparing the genomes of animal species have revealed new insights into the evolutionary forces at work over millions of years.

Biology와 Sociology를 함께 공부한 후에, Bioethics관련 Master를 취득해보세요.
한국에는 아직 없지만, 이곳에서는 Bioethics에 관한 이슈가 뜨겁게 달아오르고 있답니다. ^^*

자라나는 청소년 여러분 파이팅!! 미래의 멋진 리더가 되세요!!
더 궁금하신 것 있으시면, 이곳으로 메일 보내 주세요. ^^

bxp12@psu.edu

아 마냥 좋은 밤이다.

^_^*

월요일 아침까지 Genomics숙제,
아침에 문제 있었던 Database도 이상없고,
오늘 오후에 Miller교수님과 긴장되었던 Bioinformatics project중간발표,
저녁에는 Colloquium 수업에 Guest speacker로 온 Dr. Jonathan K. Pritchard과의 미팅까지 마치고...

그리고,
오랜만에 여유로운 시간을 가져본다.
J형님이 보내주신, 잔잔한 사랑 메시지의 재즈음악을 듣고

즐거운 하루였다.
아직도 몸 속에 곳곳이 긴장감이 서려 있지만,
그래도 잠깐 동안의 여유로움은 너무나 좋네.

이번학기 이제 6주남았다!
앞으로 3주는 가장 바쁠것 같다.
그리고 한주의 Thanksgiving을 마치면,
2주의 마지막 스파트를 끝내고 이번학기를 마치게 된다.

이번학기 끝나면 얼마나 행복할까?
아~~~!!!
해피해피!!

^_^*

Quando Quando Quando

Richard A. Young

Department of Biology, MIT

Kolmogorov–Smirnov test

In statistics, the Kolmogorov–Smirnov test (K–S test) is a form of minimum distance estimation used as a nonparametric test of equality of one-dimensional probability distributions used to compare a sample with a reference probability distribution (one-sample K–S test), or to compare two samples (two-sample K–S test). The Kolmogorov–Smirnov statistic quantifies a distance between the empirical distribution function of the sample and the cumulative distribution function of the reference distribution, or between the empirical distribution functions of two samples. The null distribution of this statistic is calculated under the null hypothesis that the samples are drawn from the same distribution (in the two-sample case) or that the sample is drawn from the reference distribution (in the one-sample case). In each case, the distributions considered under the null hypothesis are continuous distributions but are otherwise unrestricted.

The two-sample KS test is one of the most useful and general nonparametric methods for comparing two samples, as it is sensitive to differences in both location and shape of the empirical cumulative distribution functions of the two samples.

The Kolmogorov–Smirnov test can be modified to serve as a goodness of fit test. In the special case of testing for normality of the distribution, samples are standardized and compared with a standard normal distribution. This is equivalent to setting the mean and variance of the reference distribution equal to the sample estimates, and it is known that using the sample to modify the null hypothesis reduces the power of a test. Correcting for this bias leads to the Lilliefors test. However, even Lilliefors' modification is less powerful for testing normality than the Shapiro–Wilk test or Anderson–Darling test.

Harvest ministry







Young, Professional, and Enthusiastic for Gospel, I'm so much impressed~!!!

1) Harvest Got Talent

2) The Motions

3) How Great Is Our God

4) Grace's Amazing Hands

5) Last Words

6) Give Him A Try

7) For the Longest Time

8) Jesus You're My Superhero

9) Only Hope

잠재력, 숨은 능력
포텐셜!

나에게 얼마나 큰 잠재력이 있을까?
나는 어떠한 삶을 살아갈까?

하루하루가 즐거운 요즘!!!
^_^*